1 00:00:00,040 --> 00:00:04,840 VO: Welcome to one of ConsExpo Web's online tutorials. 2 00:00:04,960 --> 00:00:08,040 This video will run you through a worked example... 3 00:00:08,160 --> 00:00:14,600 showcasing the functionality of ConsExpo Web software in an exposure assessment. 4 00:00:15,440 --> 00:00:20,480 The worked example is based on a scenario for an all-purpose cleaner. 5 00:00:20,600 --> 00:00:22,880 The exposure to chemical X... 6 00:00:23,000 --> 00:00:28,880 is assessed for both short-term peak exposure and long-term exposure. 7 00:00:29,000 --> 00:00:31,840 The scenario is described as follows: 8 00:00:31,960 --> 00:00:35,920 the product user sprays an amount of product on a surface. 9 00:00:36,040 --> 00:00:38,800 The surface is then rinsed with a cloth. 10 00:00:38,920 --> 00:00:44,440 After the cleaning has taken place, a child plays on the surface that has been cleaned. 11 00:00:44,560 --> 00:00:48,120 The all-purpose cleaner can be used everywhere in the house... 12 00:00:48,240 --> 00:00:54,080 but is typically used for a small surface up to about 1 m2. 13 00:00:54,200 --> 00:00:58,200 From this description we establish two phases of application... 14 00:00:58,320 --> 00:01:02,760 namely the spraying phase and consequently rinsing phase. 15 00:01:02,880 --> 00:01:06,120 In addition, we have a post-application phase... 16 00:01:06,240 --> 00:01:11,600 describing the exposure of chemical X to a child while playing. 17 00:01:11,720 --> 00:01:13,240 In ConsExpo Web... 18 00:01:13,360 --> 00:01:18,920 a separate assessment is required in case a different subpopulation is considered. 19 00:01:19,040 --> 00:01:23,000 Thus, for the worked example we will create two assessments... 20 00:01:23,120 --> 00:01:26,480 starting with the adult user of the spray. 21 00:01:27,720 --> 00:01:31,720 It is important to realise that ConsExpo requires information... 22 00:01:31,840 --> 00:01:38,400 on product, substance, exposed person and residential settings. 23 00:01:39,600 --> 00:01:43,280 First, we consider the spraying of the all-purpose cleaner. 24 00:01:43,400 --> 00:01:46,720 In case the volatility is unknown or known to be high... 25 00:01:46,840 --> 00:01:52,120 the first tier spray model for volatile substances should be selected. 26 00:01:52,240 --> 00:01:57,600 Here, we regard chemical X as non-volatile and select the spray model. 27 00:01:57,720 --> 00:02:01,720 We use the use factsheet functionality in ConsExpo... 28 00:02:01,840 --> 00:02:05,120 to select the cleaning and washing factsheet... 29 00:02:05,240 --> 00:02:10,000 all purpose cleaner and finally the all purpose cleaner spray. 30 00:02:10,120 --> 00:02:14,880 Then select the option for non-volatile substances. 31 00:02:15,920 --> 00:02:20,800 The factsheets provide underlying information for this standard scenario. 32 00:02:20,920 --> 00:02:25,040 As the assessor you have to make sure that the scenario in the fact sheet... 33 00:02:25,160 --> 00:02:27,680 matches your own scenario. 34 00:02:27,800 --> 00:02:32,480 The scenario description can be found in the cleaning agents fact sheet. 35 00:02:32,600 --> 00:02:36,720 It is a perfect match, except for the spraying location. 36 00:02:37,720 --> 00:02:39,360 Since it can be used everywhere... 37 00:02:39,480 --> 00:02:43,040 we need to adapt the room volume and room ventilation... 38 00:02:43,160 --> 00:02:46,480 to match the defaults for an unspecified room... 39 00:02:46,600 --> 00:02:49,960 as described in the General fact sheet. 40 00:02:50,720 --> 00:02:55,800 Product and substance specific information next to population information... 41 00:02:55,920 --> 00:02:59,120 is to be added to complete the scenario. 42 00:02:59,240 --> 00:03:03,320 When all insert fields are filled in for the inhalation exposure... 43 00:03:03,440 --> 00:03:06,000 the exposure can be simulated. 44 00:03:08,200 --> 00:03:11,640 Within this assessment a second scenario can be added... 45 00:03:11,760 --> 00:03:15,640 in the same way as the spraying scenario was created. 46 00:03:15,760 --> 00:03:19,320 Using the use factsheet button under scenario... 47 00:03:19,440 --> 00:03:23,280 the scenario for rinsing can be selected and created... 48 00:03:23,400 --> 00:03:27,840 with again the necessary changes as previously indicated. 49 00:03:29,040 --> 00:03:31,480 The exposure assessment can be simulated... 50 00:03:31,600 --> 00:03:35,040 for both scenarios simultaneously. 51 00:03:35,160 --> 00:03:38,640 The exposure estimated for the dose can be summed... 52 00:03:38,760 --> 00:03:43,480 to determine the exposure resulting from both spraying and wiping. 53 00:03:43,600 --> 00:03:49,640 But be aware that ConsExpo does not limit the exposure estimate for mass balance. 54 00:03:49,760 --> 00:03:52,200 Each scenario is calculated... 55 00:03:52,320 --> 00:03:56,240 as if the product amount is independent of the other. 56 00:03:57,560 --> 00:04:01,360 If a health reference value is available for chemical X... 57 00:04:01,480 --> 00:04:06,280 the assessor can compare the different exposure metrics ConsExpo provided... 58 00:04:06,400 --> 00:04:11,520 with the reference value to see if risks are sufficiently controlled. 59 00:04:11,640 --> 00:04:15,240 The exposure assessment then continues with a new assessment... 60 00:04:15,360 --> 00:04:18,480 for the child playing on the treated surface. 61 00:04:18,600 --> 00:04:22,160 Again, there is a scenario available from the factsheets... 62 00:04:22,280 --> 00:04:27,160 that describes the rubbing off of substance from a treated surface. 63 00:04:27,280 --> 00:04:30,000 The duplicate assessment button can be pressed... 64 00:04:30,120 --> 00:04:35,840 to create a duplicate that can serve as the basis for the new assessment. 65 00:04:35,960 --> 00:04:41,280 First, change the assessment settings regarding the population of interest. 66 00:04:41,400 --> 00:04:46,480 Then, the scenarios previously set up for the application should be removed... 67 00:04:46,600 --> 00:04:51,880 and a new scenario should be created for the post-application phase. 68 00:04:52,000 --> 00:04:54,480 But there is a catch. 69 00:04:55,120 --> 00:04:58,960 Using the use factsheet functionality in ConsExpo... 70 00:04:59,080 --> 00:05:03,200 to select the cleaning and washing factsheet, all-purpose cleaner... 71 00:05:03,320 --> 00:05:09,800 and finally the all-purpose cleaner spray, one cannot find a post-application phase. 72 00:05:09,920 --> 00:05:15,040 However, there is a post-application phase in the all-purpose cleaner liquid. 73 00:05:15,160 --> 00:05:16,720 This makes sense. 74 00:05:16,840 --> 00:05:20,400 Typically one does not use sprays for large surface areas... 75 00:05:20,520 --> 00:05:23,200 but rather use a liquid cleaner. 76 00:05:23,320 --> 00:05:27,720 In our situation though, we do consider a post application phase... 77 00:05:27,840 --> 00:05:31,600 where a child plays on the treated surface. 78 00:05:32,840 --> 00:05:36,600 To accommodate the scenario of the exposure of a playing child... 79 00:05:36,720 --> 00:05:41,760 to an area treated with the spray, the assessor reassesses the treated area... 80 00:05:41,880 --> 00:05:45,960 and reduces the default parameter value for contacted surface... 81 00:05:46,080 --> 00:05:49,880 to, in this example, 1 m2. 82 00:05:50,880 --> 00:05:54,360 Also note that the spraying takes place every day. 83 00:05:54,480 --> 00:05:58,640 The frequency of the use of the liquid is much lower. 84 00:05:58,760 --> 00:06:03,880 The scenario therefore needs another adjustment regarding the frequency. 85 00:06:05,040 --> 00:06:10,120 Probably not all spray applications are on surfaces where a child will play. 86 00:06:10,240 --> 00:06:14,160 In the example, it is assumed that this scenario follows the information... 87 00:06:14,280 --> 00:06:17,040 on frequency for the cleaner liquid. 88 00:06:17,160 --> 00:06:23,800 The frequency of play on a treated surface is 197 times per year. 89 00:06:24,360 --> 00:06:27,920 If inhalation exposure during the spray application... 90 00:06:28,040 --> 00:06:30,400 is expected for the child as well... 91 00:06:30,520 --> 00:06:36,000 a separate scenario should be added as described for the adult user previously. 92 00:06:36,120 --> 00:06:40,480 For now, we continue with the dermal exposure route only. 93 00:06:41,480 --> 00:06:47,680 The scenario is now completed and can be run by clicking the simulate button. 94 00:06:47,800 --> 00:06:53,640 Both the dermal load and dermal systemic exposure are provided. 95 00:06:53,760 --> 00:06:56,760 Dependent on the type of health reference value... 96 00:06:56,880 --> 00:07:00,120 possibly specific for this target population... 97 00:07:00,240 --> 00:07:04,320 one can compare the appropriate dose metric with the reference value... 98 00:07:04,440 --> 00:07:07,800 and see if risks are sufficiently controlled. 99 00:07:09,080 --> 00:07:13,720 Using the functionality in ConsExpo under the assessments window... 100 00:07:13,840 --> 00:07:18,520 one can create a report per assessment for multiple scenarios... 101 00:07:18,640 --> 00:07:21,200 create graphs and so on. 102 00:07:21,320 --> 00:07:23,280 Outside of ConsExpo Web... 103 00:07:23,400 --> 00:07:27,720 the assessor needs to report their findings regarding the risks. 104 00:07:27,840 --> 00:07:32,600 The features of ConsExpo end with the exposure assessment. 105 00:07:32,720 --> 00:07:38,400 We hope this tutorial has helped you to familiarise yourself with ConsExpo Web. 106 00:07:38,520 --> 00:07:42,960 Our support does not end here. On the ConsExpo website... 107 00:07:43,080 --> 00:07:47,320 you can find Help-pages that provide information on ConsExpo Web... 108 00:07:47,440 --> 00:07:49,720 and a user manual. 109 00:07:49,840 --> 00:07:55,680 You can also access the 'i' and '?' icons within the software... 110 00:07:55,800 --> 00:07:59,560 which are there to give you that extra help when needed. 111 00:07:59,680 --> 00:08:02,640 If you still have questions or need assistance... 112 00:08:02,760 --> 00:08:11,280 please contact us at: consexpo@rivm.nl.