1 00:00:00,040 --> 00:00:03,800 VOICE-OVER: Welcome to one of ConsExpo Web's online tutorials. 2 00:00:03,920 --> 00:00:07,360 This video will give you insight into the oral exposure models... 3 00:00:07,480 --> 00:00:10,880 that are used in the ConsExpo Web software. 4 00:00:11,000 --> 00:00:14,680 Oral exposure from using non-food consumer products... 5 00:00:14,800 --> 00:00:21,600 is typically the result of unintended contact or related to the incorrect use of a product. 6 00:00:21,720 --> 00:00:27,480 Only teething rings and toys for the very young are intended for oral exposure. 7 00:00:27,600 --> 00:00:33,440 Within ConsExpo Web, three types of oral exposure are distinguished. 8 00:00:33,560 --> 00:00:37,160 The first is direct ingestion from products... 9 00:00:37,280 --> 00:00:41,760 or through contaminated fingers that come into contact with the mouth. 10 00:00:41,880 --> 00:00:46,000 The second is oral exposure to food packaging materials... 11 00:00:46,120 --> 00:00:49,000 through the consumption of food. 12 00:00:49,120 --> 00:00:51,560 The third is secondary ingestion... 13 00:00:51,680 --> 00:00:55,760 through the inhalation of aerosols from spray application. 14 00:00:56,680 --> 00:01:01,160 The direct ingestion model is subdivided into three modes. 15 00:01:01,280 --> 00:01:08,160 The direct oral intake mode, the constant rate mode and the product mouthing mode. 16 00:01:08,280 --> 00:01:11,160 Direct oral intake is a low-tier mode... 17 00:01:11,280 --> 00:01:15,080 that describes the amount of the product ingested directly. 18 00:01:15,200 --> 00:01:18,720 It is suitable to describe accidental oral exposure... 19 00:01:18,840 --> 00:01:22,800 or in cases when details regarding oral exposure are lacking. 20 00:01:22,920 --> 00:01:26,560 The mode requires information on the ingested amount... 21 00:01:26,680 --> 00:01:30,000 the weight fraction of the substance and body weight... 22 00:01:30,120 --> 00:01:33,920 to determine the exposure per unit of body weight. 23 00:01:34,040 --> 00:01:38,360 The constant rate model describes ingestion per unit of time. 24 00:01:38,480 --> 00:01:43,080 This mode can be used to refine the direct oral intake mode... 25 00:01:43,200 --> 00:01:45,360 when information on the period of time... 26 00:01:45,480 --> 00:01:49,360 someone has ingested a product or material is available. 27 00:01:49,480 --> 00:01:52,120 The mode requires a rate and duration. 28 00:01:52,240 --> 00:01:56,240 It can also be used to describe mouthing behaviour. 29 00:01:56,360 --> 00:02:02,480 However, a more suitable mode to describe mouthing behaviour is described next. 30 00:02:02,600 --> 00:02:04,360 The product mouthing mode... 31 00:02:04,480 --> 00:02:09,320 describes the migration process of a substance to the mouth during mouthing. 32 00:02:09,440 --> 00:02:12,480 The migration rate is described as the amount of substance... 33 00:02:12,600 --> 00:02:17,640 that is released per product surface area mouthed per second. 34 00:02:17,760 --> 00:02:23,200 This mode is used for typical mouthing scenarios with toys or baby products... 35 00:02:23,320 --> 00:02:26,160 and when the migration rate is known. 36 00:02:26,760 --> 00:02:28,640 The more product is mouthed... 37 00:02:28,760 --> 00:02:31,960 the longer and the faster a substance is released... 38 00:02:32,080 --> 00:02:35,160 and therefore the higher the exposure will be. 39 00:02:35,280 --> 00:02:39,920 The next model is the migration from packaging material model. 40 00:02:40,040 --> 00:02:44,440 It describes indirect exposure to substances from packaging material... 41 00:02:44,560 --> 00:02:46,920 that migrated into food. 42 00:02:47,040 --> 00:02:50,200 It has two modes describing the way a substance migrates... 43 00:02:50,320 --> 00:02:53,000 from the packaging material to the food. 44 00:02:53,120 --> 00:02:57,320 The instant release mode and the constant release mode. 45 00:02:57,440 --> 00:03:00,800 The model describes the step during which the substance migrates... 46 00:03:00,920 --> 00:03:05,400 from the packaging material to the food, which is then consumed. 47 00:03:05,520 --> 00:03:08,160 When selecting the constant release mode... 48 00:03:08,280 --> 00:03:11,760 storage time is relevant to determine the concentration... 49 00:03:11,880 --> 00:03:16,320 that may have already migrated to the food prior to consumption. 50 00:03:16,440 --> 00:03:21,040 The information on migration is vital for the use of this model. 51 00:03:21,160 --> 00:03:26,200 Finally, a model is available to the user that describes secondary ingestion... 52 00:03:26,320 --> 00:03:30,200 resulting from the inhalation of spray particles. 53 00:03:30,320 --> 00:03:34,160 This model is an option when using the spray model. 54 00:03:34,280 --> 00:03:37,480 In the spray model, there is a tick box marked... 55 00:03:37,600 --> 00:03:41,680 'Include oral non-respirable material exposure'. 56 00:03:41,800 --> 00:03:45,560 When selected, the model assumes that inhaled spray particles... 57 00:03:45,680 --> 00:03:49,760 that do not enter the respiratory tract are ingested. 58 00:03:49,880 --> 00:03:52,160 By default, it considers sprays... 59 00:03:52,280 --> 00:03:57,360 in the range between 15 and 50 micrometres in diameter. 60 00:03:57,480 --> 00:04:00,640 The model calculates the oral exposure itself... 61 00:04:00,760 --> 00:04:06,200 and does not require more information than already required for the spray model. 62 00:04:07,000 --> 00:04:12,960 We hope this tutorial has helped you to familiarise yourself with ConsExpo Web. 63 00:04:13,080 --> 00:04:15,200 Our support does not end here. 64 00:04:15,320 --> 00:04:18,480 Visit the ConsExpo website for help pages... 65 00:04:18,600 --> 00:04:23,080 that provide information on ConsExpo Web and a user manual. 66 00:04:23,200 --> 00:04:28,360 You can also access the 'i' and '?' icons within the software... 67 00:04:28,480 --> 00:04:31,480 which are there to give you extra help when needed. 68 00:04:31,600 --> 00:04:34,120 If you still have questions or need assistance... 69 00:04:34,240 --> 00:04:43,200 please contact us at consexpo@rivm.nl.